Application

CBS Catalysts for Asymmetric Reduction and Asymmetric Synthesis

The CBS (Corey-Bakshi-Shibata) oxazaborolidine catalyst has been used in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C₂ symmetrical ferrocenyl diols, and propargyl alcohols.Used in a desymmetrizing reduction leading to (S)-4-hydroxycyclohexenone.

Excellent catalyst of asymmetric reductions.

(R)-(+)-2-Methyl-CBS-oxazaborolidine solution [1M in toluene] may be used as a catalyst in the asymmetric borane reduction of perfluoroalkyl ketones. It may also be used in the preparation of: (-)-diospongin B(1R)-2-azido-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol(S)-α-deuteriobenzyl alcohol(3S,4R,5S)-1-(trimethylsilyl)-4,5-epoxyhex-1-yn-3-ol

Packaging

5 mL in glass bottle

25 mL in Sure/Seal™

Physical form

Precipitate may form in storage, but does not affect product quality. Gently heat product to 80−90 °C under an inert atmosphere to redissolve solids.